Journal article
FoxO1 is required for physiological cardiac hypertrophy induced by exercise but not by constitutively active PI3K
KL Weeks, YK Tham, SG Yildiz, Y Alexander, DG Donner, H Kiriazis, CA Harmawan, A Hsu, BC Bernardo, A Matsumoto, RA DePinho, E Dale Abel, EA Woodcock, JR McMullen
American Journal of Physiology Heart and Circulatory Physiology | Published : 2021
Abstract
The insulin-like growth factor 1 receptor (IGF1R) and phosphoinositide 3-kinase p110a (PI3K) are critical regulators of exercise-induced physiological cardiac hypertrophy and provide protection in experimental models of pathological remodeling and heart failure. Forkhead box class O1 (FoxO1) is a transcription factor that regulates cardiomyocyte hypertrophy downstream of IGF1R/ PI3K activation in vitro, but its role in physiological hypertrophy in vivo was unknown. We generated cardiomyocyte-specific FoxO1 knockout (cKO) mice and assessed the phenotype under basal conditions and settings of physiological hypertrophy induced by 1) swim training or 2) cardiac-specific transgenic expression of ..
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Grants
Awarded by Baker Foundation
Funding Acknowledgements
This study was funded by a National Health and Medical Research Council project grant to J.R.M. and E.A.W. (ID 526647) and in part by the Victorian Government's Operational Infrastructure Support Program. K.L.W. is supported by a Future Leader Fellowship from the National Heart Foundation of Australia (award ID 102539). B.C.B. is supported by an Alice Baker and Eleanor Shaw Fellowship (The Baker Foundation, Australia). J.R.M. is supported by a National Health and Medical Research Council Senior Research Fellowship (ID 1078985).